Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients

• Kiyosue Arihiro

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Hirata Yasunobu

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Ando Jiro

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Fujita Hideo

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Morita Toshihiro

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Takahashi Masao

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Nagata Daisuke

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Kohro Takahide

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Imai Yasushi

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

• Nagai Ryozo

  Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

抄録

Background: The relationship between renal dysfunction and the severity of coronary artery disease (CAD) was examined. Methods and Results: The severity of CAD in 572 patients was graded according to the number of stenotic coronary arteries, and the estimated glomerular filtration rate (eGFR) was monitored for 3 years. Patients were stratified into 3 eGFR groups: normal (>75 ml · min^-1 · 1.73 m^-2), mild reduction (60-75) and chronic kidney disease (CKD: <60). There were 161 patients in the CKD group. The average number of stenotic coronary arteries was larger in the CKD group than in the other groups (normal vs mild reduction vs CKD =1.35±0.07 (SE) vs 1.22±0.08 vs 1.69±0.08 vessel disease (VD), P<0.001). During the 3-year follow-up, the renal function of 13.8% of the patients worsened. Those who showed more deterioration of eGFR had more severe CAD than those who did not (1.20±0.06 vs 1.61±0.06 VD, P<0.001). Multivariate analysis revealed that the severity of CAD was independently and significantly associated with the deterioration of eGFR. Conclusions: Patients with CKD had more severe CAD, which may explain the high rate of cardiovascular events in these patients. Moreover, the prognosis of renal function was poor in patients with severe CAD, and CAD was found to be an independent risk factor for worsening of renal dysfunction. (Circ J 2010; 74: 786-791)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (4), 786-791, 2010

  一般社団法人 日本循環器学会

キーワード

• Chronic kidney disease
• Coronary artery disease
• Glomerular filtration rate
• Renal function

詳細情報

• CRID: 1390282680078607232
• NII論文ID: 10026472745
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-09-0715
• COI: 1:CAS:528:DC%2BC3cXls1Skt7k%3D
• ISSN: 13474820
• ISSN: 13469843
• ISSN: http://id.crossref.org/issn/13469843
• PubMed: 20160394
• Web Site: http://www.jstage.jst.go.jp/article/circj/74/4/74_CJ-09-0715/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010240003
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可