Development of polymeric micelles for innovative photodynamic therapy

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  • Nishiyama Nobuhiro
    Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo
  • Morimoto Yuji
    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College
  • Kataoka Kazunori
    Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo

Bibliographic Information

Other Title
  • ダブルターゲティング：薬物と医療機器テクノロジーの融合　　革新的光線力学療法のための高分子ミセル型ＤＤＳの設計
  • 革新的光線力学療法のための高分子ミセル型DDSの設計
  • カクシンテキ コウセン リキガク リョウホウ ノ タメ ノ コウブンシ ミセルガタ DDS ノ セッケイ

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Abstract

Photodynamic therapy (PDT) is an effective method for the treatment of superficial and early-stage cancers. The use of DDS for the delivery of photosensitizers is a promising approach for improved safety and enhanced efficacy of PDT. In this regard, we have developed polymeric micelles incorporating dendritic photosensitizers and demonstrated their usefulness in animal studies.<BR>Also, we have established an innovative PDT system using the combination of polymeric micelles and light irradiation device for diagnosis and treatment of microcarcinoma.

Journal

  • Drug Delivery System

    Drug Delivery System 25 (5), 448-455, 2010

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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