Sensitive Analysis of Blonanserin, a Novel Antipsychotic Agent, in Human Plasma by Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

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  • OGAWA Tadashi
    Department of Legal Medicine, Aichi Medical University School of Medicine
  • HATTORI Hideki
    Department of Legal Medicine, Aichi Medical University School of Medicine
  • KANEKO Rina
    Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
  • ITO Kenjiro
    Department of Legal Medicine, Aichi Medical University School of Medicine
  • IWAI Masayo
    Department of Legal Medicine, Aichi Medical University School of Medicine
  • MIZUTANI Yoko
    Department of Legal Medicine, Aichi Medical University School of Medicine
  • ARINOBU Tetsuya
    Department of Chemistry, Aichi Medical University School of Medicine
  • ISHII Akira
    Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
  • SUZUKI Osamu
    Department of Legal Medicine, Hamamatsu University School of Medicine
  • SENO Hiroshi
    Department of Legal Medicine, Aichi Medical University School of Medicine

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抄録

A rapid and sensitive method for analysis of blonanserin in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry is presented. After pretreatment of a plasma sample by solid-phase extraction, blonanserin was analyzed by the system with a C18 column. This method gave satisfactory recovery rates, reproducibility, and good linearity of calibration curve in the range of 0.01 – 10.0 ng/mL for quality control samples spiked with blonanserin. The detection limit was as low as 1 pg/mL. This method seems very useful in forensic and clinical toxicology and pharmacokinetic studies.

収録刊行物

  • Analytical Sciences

    Analytical Sciences 26 (10), 1099-1102, 2010

    社団法人 日本分析化学会

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