書誌事項
- タイトル別名
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- Design and Characterization of Partially Fluorinated Lipid Liquid-Crystal Membranes as Biomaterials
- バイオ ザイリョウ ト シテ ノ ブブン ガン フッソ シシツ エキショウ マク ノ セッケイ ト トクセイカ
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This article reviews our approaches for designing fluorinated lipid liquid–crystal membranes suitable for biomaterials such as membrane protein reconstitution matrices. We proposed several partially fluorinated fatty acids as well as phospholipids bearing long (C18) hydrophobic chains comparable to biomembrane lipids. The fatty acids and/or phospholipids containing perfluoroalkyl group was easily synthesized in good yields. Judging from the collapse (equilibrium spreading) pressures of the proposed fatty aids and/or phospholipids at the air–water interface, the partial fluorination of hydrophobic chains was enough to improve their monolayer stability. The fluorinated phospholipid with C–C triple bonds formed flexible structures such as stable vesicles in water at a room temperature. The partially fluorinated phospholipids are applicable to protein reconstitution matrices, e.g., reconstitution of photosynthetic membrane proteins.
収録刊行物
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- 有機合成化学協会誌
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有機合成化学協会誌 68 (3), 206-216, 2010
公益社団法人 有機合成化学協会
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詳細情報 詳細情報について
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- CRID
- 1390282680289892096
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- NII論文ID
- 10026868098
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- NII書誌ID
- AN0024521X
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- COI
- 1:CAS:528:DC%2BC3cXjt1yrurY%3D
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- ISSN
- 18836526
- 00379980
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- NDL書誌ID
- 10612629
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可