遺伝的背景や性, 週齢がマウスに対するルブラトキシンBの毒性に与える影響
書誌事項
- タイトル別名
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- Effects of genetics, sex, and age on the toxicity of rubratoxin B in mice
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To improve an animal model used in toxicological studies, we investigated the effects of genetics, sex, and age on rubratoxin B toxicity in mice. Treatment with rubratoxin B for 24 h increased serum alanine aminotransferase (ALT) activity, a common indicator of hepatic injury, in C3H/He, BALB/c, DBA/2, and C57BL/6 mice. The increase in serum ALT levels was most pronounced in rubratoxin B-treated C3H/He mice, as was the decrease in serum glucose concentration. In addition, these effects were greater in C3H/He male mice than female. Serum ALT activities were more elevated in rubratoxin B-exposed 9- and 12-week-old animals than that of 6-week-olds. The effect of rubratoxin B on the serum glucose concentration was greatest in 9-week-old male C3H/He mice. Therefore, our findings show that the genetics, sex, and age of the mice treated all contributed to the toxicity of rubratoxin B and that 9-week-old male C3H/He mice were the most susceptible of the animals we tested. Moreover, rubratoxin B-exposed mice had fatty livers and increased levels of triglycerides (the typical lipid involved in the development of fatty liver).
収録刊行物
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- マイコトキシン
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マイコトキシン 55 (1), 35-42, 2005
日本マイコトキシン学会
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詳細情報 詳細情報について
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- CRID
- 1390282679760436480
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- NII論文ID
- 10026891000
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- NII書誌ID
- AN00334513
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- COI
- 1:CAS:528:DC%2BD2MXhtFSksrnF
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- ISSN
- 18810128
- 02851466
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可