Field study: Paraoxonase 1 correlates with butyrylcholinesterase and gamma glutamyl transferase in workers chronically exposed to pesticides
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- Araoud Manel
- Laboratory of Biochemistry 05/UR/09-09, Faculty of Medicine of Monastir Laboratory of Biochemistry-Toxicology, University Hospital Fattouma Bourguiba Monastir
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- Neffeti Fadoua
- Laboratory of Biochemistry-Toxicology, University Hospital Fattouma Bourguiba Monastir
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- Douki Wahiba
- Laboratory of Biochemistry-Toxicology, University Hospital Fattouma Bourguiba Monastir
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- Najjar Mohamed Fadhel
- Laboratory of Biochemistry-Toxicology, University Hospital Fattouma Bourguiba Monastir
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- Kenani Abderraouf
- Laboratory of Biochemistry 05/UR/09-09, Faculty of Medicine of Monastir
書誌事項
- タイトル別名
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- Paraoxonase 1 Correlates with Butyrylcholinesterase and Gamma Glutamyl Transferase in Workers Chronically Exposed to Pesticides
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Objectives: Agricultural workers chronically exposed to complex mixtures of pesticides are at increased risk of acute and chronic toxicity of these compounds. Enzyme activities are among the biomarkers that may be used to detect the effects of pesticides before adverse clinical health effects occur. The aims of this study were to ascertain the relationships between paraoxonase 1 (PON1) and other serum enzymes and to investigate whether long-term exposure to pesticides affects these relationships in Tunisian agricultural workers. Methods: The activities of butyrylcholinesterase (BChE), aminotransferases, gamma glutamyl transferase (GGT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase (CK) were measured in plasma from workers chronically exposed to pesticides using an Integra 400 plusTM system. PON1 activity was measured using konelab 30TM system. Results: Significant increases in aminotransferases, CK, LDH and ALP activities were found in workers exposed to pesticides. However, BChE and PON1 activities were decreased significantly in these subjects. In addition, PON1 activity was positively correlated with both BChE and GGT activities in these workers. Conclusion: This study suggests that pesticides lead to alteration of serum enzymes and that chronic exposure to pesticides might contribute to explain the positive correlation between PON1 and GGT, perhaps in order to protect BChE and simultaneously induce detoxification of pesticides.<br>
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 52 (6), 383-388, 2010
公益社団法人 日本産業衛生学会
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詳細情報 詳細情報について
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- CRID
- 1390282679431960704
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- NII論文ID
- 10026964722
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 10903360
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可