Cyclophilin A - Promising New Target in Cardiovascular Therapy -

DOI Web Site PubMed 被引用文献21件 参考文献166件
  • Satoh Kimio
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Shimokawa Hiroaki
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine
  • Berk Bradford C.
    Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry

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  • – Promising New Target in Cardiovascular Therapy –

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Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms. (Circ J 2010; 74: 2249-2256)<br>

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  • Circulation Journal

    Circulation Journal 74 (11), 2249-2256, 2010

    一般社団法人 日本循環器学会

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