Update on the role of endothelial lipase in HDL metabolism, reverse cholesterol transport, and atherosclerosis

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  • Yasuda Tomoyuki
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine Division of Cardiovascular Medicine, Kobe University Graduate school of Medicine
  • Ishida Tatsuro
    Division of Cardiovascular Medicine, Kobe University Graduate school of Medicine
  • Rader Daniel J.
    Institute for Translational Medicine and Therapeutics and Cardiovascular Institute, University of Pennsylvania School of Medicine

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タイトル別名
  • Update on the Role of Endothelial Lipase in High-Density Lipoprotein Metabolism, Reverse Cholesterol Transport, and Atherosclerosis

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Endothelial lipase (EL) is a phospholipase that belongs to the lipoprotein lipase (LPL) family, which includes LPL and hepatic lipase (HL). Similar to LPL and HL, EL regulates lipoprotein metabolism, mainly high-density lipoprotein (HDL) metabolism and HDL cholesterol (HDL-C) levels in humans and mice. Existing data strongly suggest that inhibition of EL in humans would be expected to increase the HDL-C level. However, it has not been definitively established whether the effect of EL activity on HDL-C levels translates into effects on reverse cholesterol transport or atherosclerosis. The available data regarding the impact of EL expression and activity on HDL metabolism, reverse cholesterol transport, and atherosclerosis are reviewed. (Circ J 2010; 74: 2263-2270)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 74 (11), 2263-2270, 2010

    一般社団法人 日本循環器学会

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