Augmented PDBu-mediated contraction of bronchial smooth muscle of mice with antigen-induced airway hyperresponsiveness

DOI Web Site 被引用文献2件 参考文献38件
  • Sakai Hiroyasu
    Department of Pharmacology, School of Pharmacy, Hoshi University
  • Kurihara Yusuke
    Department of Pharmacology, School of Pharmacy, Hoshi University
  • Hashimoto Yuki
    Department of Pharmacology, School of Pharmacy, Hoshi University
  • Chiba Yoshihiko
    Department of Pharmacology, School of Pharmacy, Hoshi University
  • Misawa Miwa
    Department of Pharmacology, School of Pharmacy, Hoshi University

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To explore the role of protein kinase C (PKC) in the augmented bronchial smooth muscle (BSM) contraction observed in the antigen-induced airway hyperresponsive (AHR) mice, the effects of a PKC activator, phorbol 12,13-dibutylate (PDBu), on BSM contraction were compared between the AHR and control mice. Actively sensitized mice were repeatedly challenged by antigen inhalation. Twenty-four hours after the final antigen challenge the isometrical contractions of the BSMs were measured. The BSM contraction induced by acetylcholine, but not high K+ depolarization, was significantly augmented in the AHR mice. In BSMs of control mice, PDBu caused a significant increase in tension when the tissues were precontracted with high K+, although PDBu itself had no effect on basal tone. The PDBu-mediated contraction was markedly augmented in BSMs of the AHR mice. These findings suggest that an increase in the PKC-mediated signaling is involved in the augmented contraction of BSMs in the antigen-induced AHR mice.<br>

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