Azoospermia factor and male infertility

• Koh, Eitetsu

• Sin, Ho-Su

• Fukushima, Masato

• Namiki, Mikio

抄録

金沢大学医薬保健研究域医学系

Recently, work has shown that azoospermia factor (AZF) microdeletions result from homologous recombination between almost identical blocks in this gene region. These microdeletions in the Y chromosome are a common molecular genetic cause of spermatogenetic failure leading to male infertility. After completion of the sequencing of the Y chromosome, the classical definition of AZFa, AZFb, and AZFc was modified to five regions, namely AZFa, P5/proximal-P1, P5/distal-P1, P4/distal-P1, and AZFc, as a result of the determination of Y chromosomal structure. Moreover, partial AZFc deletions have also been reported, resulting from recombination in their sub-ampliconic identical pair sequences. These deletions are also implicated in a possible association with Y chromosome haplogroups. In this review, we address Y chromosomal complexity and the modified categories of the AZF deletions. Recognition of the association of Y deletions with male infertility has implications for the diagnosis, treatment, and genetic counseling of infertile men, in particular candidates for intracytoplasmic sperm injection. © 2010 Japan Society for Reproductive Medicine.

収録刊行物

• Reproductive Medicine and Biology

  Reproductive Medicine and Biology 9 (3), 129-139, 2010-09-01

  Springer Verlag (Germany)

キーワード

• AZF
• Intrachromosomal recombination
• Male infertility
• Palindrome
• Y chromosome

詳細情報

• CRID: 1050845760880888704
• NII論文ID: 10027050530
• NII書誌ID: AA11706516
• ISSN: 14455781
• Web Site: http://hdl.handle.net/2297/24583
• Web Site: https://search.jamas.or.jp/link/ui/2011222193
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles