THE DIFFERENCE BETWEEN GROSS TUMOR VOLUME AND BIOLOGICAL TARGET VOLUME IN POSTOPERATIVE LOCAL RECURRENT RECTAL CANCER; A PRELIMINARY STUDY OF PET/CT RADIATION THERAPY PLANNING

• JINGU Keiichi

  Department of Radiation Oncology, Tohoku University School of Medicine

• TAKEDA Ken

  Department of Radiation Oncology, Tohoku University School of Medicine

• METOKI Takahiro

  Department of Radiation Oncology, Tohoku University School of Medicine

• OGAWA Yoshihiro

  Department of Radiation Oncology, Tohoku University School of Medicine

• ARIGA Hisanori

  Department of Radiation Oncology, Tohoku University School of Medicine

• YAMADA Shogo

  Department of Radiation Oncology, Tohoku University School of Medicine

• TAKAI Yoshihiro

  Course of Health Sciences, Tohoku University School of Medicine

• HOSOGAI Yoshiyuki

  Course of Health Sciences, Tohoku University School of Medicine

• KANEDA Tomohiro

  Department of Diagnostic Radiology, Tohoku University School of Medicine

• MITSUYA Masatoshi

  Department of Radiology, Tohoku University Hospital

• WATANABE Satoru

  Department of Radiology, Tohoku University Hospital

Bibliographic Information

Other Title

• 直腸癌術後再発に対するPET/CT planningに関する初期研究～GTVとBTVの相違～

Abstract

Purpose: To reveal the difference of gross tumor volume (GTV) in CT with biological target volume (BTV) in positron emission tomography using 18F-fluorodeoxyglucose with computed tomography (FDG-PET/CT).<br>Materials and Methods: In 7 patients with postoperative local recurrence rectal cancer, three independent radiation oncologists delineated target volume on CT and PET, respectively, and compared the volume of GTV with that of BTV using the two-factor repeated measures ANOVA. FDG-PET/CT was performed in the same position as radiotherapy. The images by CT and PET were sent to the radiation therapy planning system as the DICOM datum, respectively, and fused those images using DICOM information. Each radiation oncologist delineated the abnormal shadow on CT as GTV and delineated macroscopically the region with high FDG accumulation using the tumor/muscle ratio.<br>Results: In those seven patients, mean GTV was 77.2±53.6 cm³ and mean BTV was 58.0±48.0 cm³, and BTV was statistically smaller than GTV (p<0.001). There was a strong correlation between GTV and BTV (r=0.952, p<0.001). In patients with local recurrent rectal cancer, there were no significant differences among radiation oncologists (F (2, 18)=0.654, MSe=5220.046, p=0.532).<br>Conclusion: There was a significant difference between the target volume on functional image (PET/CT) and the target volume on morphologic image (CT) in the patients with local recurrent rectal cancer.

Journal

• The Journal of JASTRO

  The Journal of JASTRO 20 (3), 127-131, 2008

  Japanese Society for Therapeutic Radiology and Oncology

Keywords

• PET/CT radiation therapy planning
• Recurrent rectal cancer
• Biological target volume

Details

• CRID: 1390282679308198656
• NII Article ID: 130004497141
• NII Article ID: 10027061082
• NII Book ID: AN10123988
• DOI: 10.11182/jastro.20.127
• ISSN: 18819885
• ISSN: 10409564
• Web Site: https://search.jamas.or.jp/link/ui/2009008535
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed