Elevated Brachial-Ankle Pulse Wave Velocity Is Associated with Left Ventricular Hypertrophy in Hypertensive Patients after Stroke
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- Masugata Hisashi
- Department of Integrated Medicine, Kagawa University
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- Senda Shoichi
- Department of Integrated Medicine, Kagawa University
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- Hoshikawa Jun
- Kagawa General Rehabilitation Center
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- Murao Koji
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Kagawa University
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- Hosomi Naohisa
- Department of Clinical Neuroscience and Therapeutics, Hiroshima University
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- Okuyama Hiroyuki
- Department of Integrated Medicine, Kagawa University
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- Inukai Michio
- Department of Integrated Medicine, Kagawa University
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- Himoto Takashi
- Department of Integrated Medicine, Kagawa University
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- Nakatsuka Yoichi
- Kagawa General Rehabilitation Center
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- Imai Masanobu
- Kagawa General Rehabilitation Center
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- Noma Takahisa
- Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University
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- Kohno Masakazu
- Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University
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- Goda Fuminori
- Department of Integrated Medicine, Kagawa University
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抄録
Brachial-ankle pulse wave velocity (baPWV) is widely used as a marker of arterial stiffness, but there are no data regarding the usefulness of measuring baPWV in hypertensive patients after stroke. The purpose of this study was to examine the clinical significance of baPWV by assessing its correlation with echocardiographic parameters in hypertensive patients after stroke. The study enrolled 61 hypertensives after stroke (24 patients with cerebral infarction and 37 with cerebral hemorrhage) and 61 age-matched hypertensives without stroke. Left ventricular (LV) hypertrophy was evaluated by measuring LV mass index (LVMI) and relative wall thickness (RWT), and LV diastolic function was evaluated by measuring peak early mitral annular velocities (E') using echocardiography. Concentric LV hypertrophy showing increased RWT (0.50 ± 0.12) was observed in hypertensives after stroke, but not in hypertensives without stroke. In hypertensives after stroke, elevated baPWV correlated with age (r = 0.60, p < 0.001), systolic blood pressure (r = 0.56, p < 0.001), increased LVMI (r = 0.47, p < 0.001), and decreased E' (r = −0.40, p = 0.002). Multiple regression analysis showed that age (β coefficient = 0.43, p < 0.001), systolic blood pressure (β coefficient = 0.40, p < 0.001), and LVMI (β coefficient = 0.25, p = 0.008) were independent determinants of elevated baPWV. In conclusion, elevated baPWV is more closely associated with LV hypertrophy than with LV diastolic dysfunction. Elevated baPWV is independently associated with the severity of LV hypertrophy adjusted with systolic blood pressure and age in hypertensive patients after stroke.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 220 (3), 177-182, 2010
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390282679220335360
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- NII論文ID
- 10027083465
- 130004459798
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- NII書誌ID
- AA00863920
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- ISSN
- 13493329
- 00408727
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可