Geriatric Medicine, Japanese Alzheimer's Disease Neuroimaging Initiative and Biomarker Development
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- Arai Hiroyuki
- Department of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging, and Cancer, Tohoku University
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- Okamura Nobuyuki
- Department of Pharmacology, Tohoku University Graduate School of Medicine
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- Furukawa Katsutoshi
- Department of Geriatrics and Gerontology, Division of Brain Science, Institute of Development, Aging, and Cancer, Tohoku University
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- Kudo Yukitsuka
- Department of Neuroimaging Research, Innovation of New Biomedical Engineering Center, Tohoku University
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抄録
Due to a change in disease spectrum in aged countries, the primary role of geriatricians should be directed to an appropriate management and prevention of 1) cognitive decline and dementia, 2) swallowing and aspiration pneumonia and 3) falls and fractures. Management of dementia constitutes a central part in the practice of geriatric medicine in order to support independence of life in elderly people. The current paradigm of cognitive function-based testing for the diagnosis and treatment of Alzheimer's disease (AD) is going to drastically shift to a biomarker-based test approach, a shift that will correspond to the emergence of disease-modifying drugs. In addition, a new molecular imaging technique that visualizes neuronal protein deposits or pathological features has been developed in Japan and the U.S.A. Based on these achievements, the Alzheimer's Disease Neuroimaging Initiative (ADNI) was proposed and initiated in 2005. The ADNI is a long-term observational study being conducted in the U.S.A., Europe, Australia, and Japan using identical protocols. The objectives of ADNI are: 1) to establish methodology which will allow standard values related to long-term changes in imaging data, such as MRI and PET, in patients with AD and mild cognitive impairment and normal elderly persons; 2) to obtain clinical indices, psychological test data, and blood/cerebrospinal fluid biomarkers to demonstrate the validity of image-based surrogate markers; and 3) to establish optimum methods to monitor the therapeutic effects of disease-modifying drugs for AD. Patient enrollment in the Japanese ADNI has begun in July 2008. Imaging of AD pathology not only acts as a reliable biomarker with which to assay curative drug development by novel pharmaceutical companies, but it also helps health promotion toward AD prevention.
収録刊行物
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- The Tohoku Journal of Experimental Medicine
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The Tohoku Journal of Experimental Medicine 221 (2), 87-95, 2010
東北ジャーナル刊行会
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詳細情報 詳細情報について
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- CRID
- 1390001204244037120
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- NII論文ID
- 10027084541
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- NII書誌ID
- AA00863920
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- ISSN
- 13493329
- 00408727
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可