骨髄間質由来成体幹細胞と組織再生

• 里村 一人

  鶴見大学歯学部口腔外科学第二（口腔内科学）講座

書誌事項

タイトル別名

• Bone marrow stroma-derived adult stem cells and tissue regeneration
• 第53回[日本口腔外科学会]総会シンポジウム「口腔外科領域における再生医療,その後の進歩」 骨髄間質由来成体幹細胞と組織再生
• ダイ53カイ ニホン コウクウ ゲカ ガッカイ ソウカイ シンポジウム コウクウ ゲカ リョウイキ ニ オケル サイセイ イリョウ ソノゴ ノ シンポ コツズイ カンシツ ユライ セイタイ カンサイボウ ト ソシキ サイセイ

抄録

Three essential factors are considered to be necessary for tissue regeneration. The first essential factor is the presence of cells that bear the function of the desired tissue or organ, the second is the presence of signals that promote proliferation and differentiation of the desired cell type, and the third is a scaffold that acts as a foundation for the cells. Of these factors, obtaining stem cells is very important. Currently, there are several different types of stem cells that may be useful in tissue regeneration, including embryonic stem cells（ES cells）, adult stem cells and induced pluripotent stem cells（iPS cells）. ES cells are derived from the inner cell mass of the early blastocyst-stage embryo. Although ES cells are known to differentiate into various functional cells derived from all three germ layers, there are ethical issues, biological limitations and technical difficulties in the application of these cells. Adult stem cells have been identified in adult tissues such as bone marrow, muscle, neural tissue, liver and the adipose tissue. Since there are no ethical problems in their use and since they are relatively easy to collect, adult stem cells may overcome the weak points of ES cells. However, some reports of short cell life spans and limitations in their differentiation potency are distinct disadvantages to the use of adult stem cells. iPS cells, which can be created by transfection of 3 or 4 genes into adult somatic cells, possess a differentiation potency equal to ES cells. iPS cells can overcome the disadvantages of ES cells and adult stem cells, but their biggest drawback is that we have to conduct transfections in order to create these cells. With these points in mind, in this review, the multipotent characteristics of bone marrow stromal cells are documented, and the possibility of their application and a new strategy for tooth regeneration are also discussed.

収録刊行物

• 日本口腔外科学会雑誌

  日本口腔外科学会雑誌 55 (10), 474-481, 2009

  社団法人 日本口腔外科学会

キーワード

• 骨髄間質細胞
• 成体幹細胞
• 多分化能
• 組織再生
• 歯の再生

詳細情報

• CRID: 1390282681510264704
• NII論文ID: 10027091067
• NII書誌ID: AN00189163
• DOI: 10.5794/jjoms.55.474
• ISSN: 21861579
• ISSN: 00215163
• NDL書誌ID: 10471453
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10471453
• Web Site: https://search.jamas.or.jp/link/ui/2010047527
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可