ビスフォスフォネート投与と関連性があると考えられた顎骨骨髄炎ならびに顎骨壊死 30 症例に関する追跡調査〜2年後の現状について〜

• 浦出 雅裕

  兵庫医科大学歯科口腔外科学講座

• 田中 徳昭

  兵庫医科大学歯科口腔外科学講座

• 嶋田 淳

  明海大学歯学部病態診断治療学講座口腔顎顔面外科学分野1

• 柴田 考典

  北海道医療大学歯学部組織再建口腔外科学講座

• 古澤 清文

  松本歯科大学口腔顎顔面外科学講座

• 桐田 忠昭

  奈良県立医科大学口腔外科学講座

• 山本 哲也

  高知大学医学部歯科口腔外科学講座

• 池邊 哲郎

  福岡歯科大学口腔・顎顔面外科学講座口腔外科学分野

• 北川 善政

  北海道大学大学院歯学研究科口腔病態学講座口腔診断内科学

• 倉科 憲治

  信州大学医学部歯科口腔外科学講座

• 瀬戸 かん一

  （社）日本口腔外科学会

• 福田 仁一

  （社）日本口腔外科学会

書誌事項

タイトル別名

• A follow-up survey of 30 cases of bisphosphonate-related ostemyelitis/ osteonecrosis of the jaws: present status after 2 years
• ビスフォスフォネート トウヨ ト カンレンセイ ガ アル ト カンガエラレタ ガクコツ コツズイエン ナラビニ ガクコツ エシ 30 ショウレイ ニ カンスル ツイセキ チョウサ 2ネンゴ ノ ゲンジョウ ニ ツイテ

抄録

Bisphosphonates（BPs）were first reported to inhibit bone resorption by Fleisch et al. in 1969. BPs are frequently used to treat bone metastatic carcinoma, hypercalcemia, multiple myeloma, and osteoporosis. However, many cases of BP-related osteonecrosis of the jaws（BRONJ）have been reported in the United States since 2003, and similar cases have also been documented in Japan since 2006. The results of the first nationwide survey of BRONJ in Japan were reported in 2007. The present report is the follow-up survey of the previous one in 2007 and describes the present status of the patients after 2 years. Twenty-eight patients were studied because 2 were ineligible. Because 9 patients were completely cured during this follow-up survey, 17 patients（60.8 ％）of all patients were completely cured. Nine（52.9 ％）of the 17 patients given intravenous BPs and 7（77.8 ％）of the 9 patients given oral BPs were completely cured. Surgical treatments, such as sequestrectomy, curettage, and resection of the jaw bone, were performed in 15（88.2 ％）of the 17 cured patients and 7（63.6 ％）of the 11 non-cured patients. Antibiotic therapy was given to 14（82.4 ％）of the cured patients and all of the non-cured patients. Drug holidays of BPs were taken in 9（52.9 ％）of the cured patients and 10（90.9 ％）of the non-cured patients. Surgical treatments appeared to be performed at a higher rate in the cured patients than in the non-cured patients. In contrast, conservative treatments were given to more non-cured patients than cured patients. These results suggest that surgical treatments may be useful for BRONJ when given at the appropriate time. In addition, BRONJ was shown to be refractory because only 9 of 17 cases were cured in these 2 years.

収録刊行物

• 日本口腔外科学会雑誌

  日本口腔外科学会雑誌 55 (11), 553-561, 2009

  社団法人 日本口腔外科学会

キーワード

• ビスフォスフォネート
• 骨壊死
• 骨髄炎
• 顎骨
• 追跡調査

詳細情報

• CRID: 1390001206532837248
• NII論文ID: 10027091304
• NII書誌ID: AN00189163
• DOI: 10.5794/jjoms.55.553
• ISSN: 21861579
• ISSN: 00215163
• NDL書誌ID: 10504035
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10504035
• Web Site: https://www.jstage.jst.go.jp/article/jjoms/55/11/55_553/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010054540
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可