Dietary zinc-deficiency and its recovery responses in rat liver cytosolic alcohol dehydrogenase activities

• Kawashima Yu

  School of Medicine, University of Yamanashi

• Someya Yui

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Sato Shogo

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University Japan Society for the Promotion of Science

• Shirato Ken

  Department of Disease Glycomics, Institute of Scientific and Industrial Research, Osaka University

• Jinde Manabu

  School of Medicine, University of Occupational and Environmental Health, Japan

• Ishida Sanshi

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Akimoto Shunta

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Kobayashi Kyoko

  Department of Living and Health Sciences, Graduate School of Education, Joetsu University of Education

• Sakakibara Yuko

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

• Suzuki Yuko

  Department of Living and Health Sciences, Graduate School of Education, Joetsu University of Education

• Tachiyashiki Kaoru

  Department of Living and Health Sciences, Graduate School of Education, Joetsu University of Education

• Imaizumi Kazuhiko

  Laboratory of Physiological Sciences, Faculty of Human Sciences, Waseda University

抄録

The purpose of the present study was to elucidate the effects of dietary zinc-deficient feeding and its recovery on liver cytosolic alcohol dehydrogenase (ADH; alcohol: NAD⁺ oxidoreductase, EC1.1.1.1) activities and plasma zinc levels in rats. The weaned male Sprague Dawley rats were randomly divided into the zinc-deficient diet (ZDF: 1.9 mg zinc/kg diet) group and the control diet (53.5 mg zinc/kg diet) group, and were fed for 4 weeks. In the recovery periods, the rats of two groups were fed with the control diet for 3 weeks. Liver cytosolic protein content per body weight in the zinc-deficiency and its recovery period showed no significant changes between both groups. However, zinc-deficiency decreased significantly liver cytosolic ADH specific activity, total liver cytosolic ADH activity and total liver cytosolic ADH activity/body weight by 50%, 76% and 53%, respectively, as compared with the control diet group. Zinc-deficiency also decreased significantly plasma zinc concentration by 84%, as compared with the control diet group. On the contrary, no significant changes in liver cytosolic ADH specific activity, total liver cytosolic ADH activity and total liver cytosolic ADH activity/body weight in the recovery period were observed between both groups. Plasma zinc concentration in the recovery period was almost recovered to the control level. These results suggest that rat liver cytosolic ADH activity was clearly related to dietary zinc intake levels.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 36 (1), 101-108, 2011

  一般社団法人　日本毒性学会

キーワード

• Zinc-deficiency and its recovery
• Zinc regulations of ethanol metabolism
• Liver alcohol dehydrogenase
• Class I ADH
• Plasma zinc
• Rat

詳細情報

• CRID: 1390282679878346752
• NII論文ID: 10027420489
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.36.101
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 10999485
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10999485
• Web Site: http://www.jstage.jst.go.jp/article/jts/36/1/36_1_101/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011323236
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可