Cardiogenesis from human embryonic stem cells

DOI Web Site 被引用文献5件 参考文献73件
  • Mignone John L.
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington Department of Medicine/Cardiology, University of Washington
  • Kreutziger Kareen L.
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington
  • Paige Sharon L.
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington
  • Murry Charles E.
    Department of Pathology, Center for Cardiovascular Biology, Institute for Stem Cell and Regenerative Medicine, University of Washington Department of Medicine/Cardiology, University of Washington Department of Bioengineering, University of Washington

書誌事項

タイトル別名
  • Cardiogenesis From Human Embryonic Stem Cells - Mechanisms and Applications -
  • – Mechanisms and Applications –

この論文をさがす

抄録

Over the past decade, the ability to culture and differentiate human embryonic stem cells (ESCs) has offered researchers a novel therapeutic that may, for the first time, repair regions of the damaged heart. Studies of cardiac development in lower organisms have led to identification of the transforming growth factor-β superfamily (eg, activin A and bone morphogenic protein 4) and the Wnt/β-catenin pathway as key inducers of mesoderm and cardiovascular differentiation. These factors act in a context-specific manner (eg, Wnt/β-catenin is required initially to form mesoderm but must be antagonized thereafter to make cardiac muscle). Different lines of ESCs produce different levels of agonists and antagonists for these pathways, but with careful optimization, highly enriched populations of immature cardiomyocytes can be generated. These cardiomyocytes survive transplantation to infarcted hearts of experimental animals, where they create new human myocardial tissue and improve heart function. The grafts generated by cell transplantation have been small, however, leading to an exploration of tissue engineering as an alternate strategy. Engineered tissue generated from preparations of human cardiomyocytes survives poorly after transplantation, most likely because of ischemia. Creation of pre-organized vascular networks in the tissue markedly enhances survival, with human capillaries anastomosed to the host coronary circulation. Thus, pathways controlling formation of the human cardiovascular system are emerging, yielding the building blocks for tissue regeneration that may address the root causes of heart failure. (Circ J 2010; 74: 2517-2526)<br>

収録刊行物

  • Circulation Journal

    Circulation Journal 74 (12), 2517-2526, 2010

    一般社団法人 日本循環器学会

被引用文献 (5)*注記

もっと見る

参考文献 (73)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ