Deep Anesthesia Suppresses Ventricular Tachyarrhythmias in Rabbit Model of the Acquired Long QT Syndrome
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- Inaba Hideko
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Hayami Noriyuki
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Ajiki Kosuke
- Department of Cardiovascular Medicine, Tokyo University
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- Kunishima Tomoyuki
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Watanabe Hidenori
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Tsutsui Kenta
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Yamagishi Noboru
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Yamagishi Satoshi
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Sugiura Anna
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Mikamo Takashi
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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- Murakawa Yuji
- Fourth Department of Internal Medicine, Teikyo University School of Medicine
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Background: Anesthesia sometimes suppresses ventricular tachyarrhythmias (VT) resistant to conventional pharmacological treatment. Methods and Results: To know (1) whether deep anesthesia inhibits abnormal repolarization-related VT and (2) if α2-adrenoreceptor (AR) agonistic action is associated with the antiarrhythmic effect of anesthetics, the incidence of VT in a rabbit model of acquired long QT syndrome using different anesthetic regimen was assessed. In Study 1 (n=30), 15 rabbits were lightly anesthetized with ketamine (123±46mg/kg) and an α2-AR agonist, xylazine (9.4±3.0mg/kg), while combination of these anesthetics at high doses were used in the other 15 rabbits (343±78mg/kg and 38.9±3.0mg/kg). Administration of α1-AR stimulant, methoxamine and nifekalant (Ikr blocker) caused VT in all lightly anesthetized rabbits. In contrast, VT was observed only in 1 of the 15 deeply anesthetized rabbits (P<0.01). In Study 2 (n=15), 10 rabbits were anesthetized with high-dose ketamine and low-dose xylazine. In the other 5 rabbits, low-dose ketamine and high-dose xylazine were used. QTc interval in the latter was longer than that of the former (399±56ms vs. 494±57ms, P<0.01). Although no VT appeared in high/low-rabbits, VT occurred in 3 out of 5 low/high-rabbits (P<0.05). Conclusions: These results suggest that (1) deep anesthesia suppresses abnormal repolarization-related VT and (2) antiarrhythmic effect of anesthesia on this type of VT is not dependent on α2-AR agonistic action. (Circ J 2011; 75: 89-93)<br>
収録刊行物
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- Circulation Journal
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Circulation Journal 75 (1), 89-93, 2011
一般社団法人 日本循環器学会
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詳細情報 詳細情報について
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- CRID
- 1390001205105117312
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- NII論文ID
- 10027425523
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- NII書誌ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
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- 使用不可