High Blood Viscosity Is Closely Associated With Cigarette Smoking and Markedly Reduced by Smoking Cessation

DOI Web Site 13 Citations 18 References
  • Shimada Sayaka
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Hasegawa Koji
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Wada Hiromichi
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Terashima Sachiko
    Health Screening Center, Kyoto Medical Center, National Hospital Organization
  • Satoh-Asahara Noriko
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Yamakage Hajime
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Kitaoka Shuji
    Health Screening Center, Kyoto Medical Center, National Hospital Organization
  • Akao Masaharu
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Shimatsu Akira
    Clinical Research Institute, Kyoto Medical Center, National Hospital Organization
  • Takahashi Yuko
    Health Administration Center, Nara Women's University

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Abstract

Background: Cigarette smoking is an independent risk factor for cardiovascular events such as myocardial infarction and stroke. To date, a useful and convenient method of predicting such events in smokers has not been established. The rheological properties of blood assessed by the microchannel method reflect the blood's viscosity and the state of microthrombus formation, which may predict cardiovascular thrombotic events. Methods and Results: Blood fluidity was assessed in 74 smoking patients (54 men, 20 women, mean age 57.9 years) by measuring the blood passage time (BPT) in an aliquot (100μl) of blood using the Micro Channel Array Flow Analyzer. BPT was significantly related with smoking variables such as daily consumption of tobacco (r=0.236, P=0.044), Brinkman's index (r=0.252, P=0.033), the Fagerstrom Test for Nicotine Dependence (r=0.257, P=0.029), and the score of a self-rating depression scale (r=0.236, P<0.05). Multivariate regression analysis revealed that an independent BPT determinant was daily consumption of tobacco (r=0.326, P=0.045). Furthermore, smoking cessation markedly decreased BPT from 63.0s to 49.7s (P=0.002) at 3 months after the start of therapy. Conclusions: Unfavorable blood rheology is closely associated with cigarette smoking and may reflect increased cardiovascular risk in smokers. The study results also suggest that such risk can be reduced after only 3 months of smoking cessation. (Circ J 2011; 75: 185-189)<br>

Journal

  • Circulation Journal

    Circulation Journal 75 (1), 185-189, 2011

    The Japanese Circulation Society

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