Effects of Combination Therapy With Warfarin and Bucolome for Anticoagulation in Patients With Atrial Fibrillation

DOI Web Site 被引用文献3件 参考文献17件
  • Obata Hiroaki
    Division of Cardiology, Niigata University School of Medical and Dental Sciences
  • Watanabe Hiroshi
    Division of Cardiology, Niigata University School of Medical and Dental Sciences
  • Ito Masahiro
    Division of Cardiology, Niigata University School of Medical and Dental Sciences
  • Hirono Satoru
    Division of Cardiology, Niigata University School of Medical and Dental Sciences
  • Hanawa Haruo
    Division of Cardiology, Niigata University School of Medical and Dental Sciences
  • Kodama Makoto
    Division of Cardiology, Niigata University School of Medical and Dental Sciences
  • Aizawa Yoshifusa
    Division of Cardiology, Niigata University School of Medical and Dental Sciences

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Background: Bucolome, a nonsteroidal antiinflammatory drug, enhances the effects of warfarin. In the present study, the effects of combination therapy (bucolome+warfarin) vs. warfarin alone on atrial fibrillation were investigated. Methods and Results: Combined therapy resulted in a decrease in the warfarin dose to approximately one-third. The fluctuations of the international normalized ratio and the time in therapeutic range were similar in both groups. There was no adverse effect in either group. Interestingly, uric acid was lower in the bucolome group. Conclusions: Bucolome enhanced the effects of warfarin, resulting in a decreased dose of warfarin without adverse effects and it showed similar anticoagulant stability to warfarin alone. (Circ J 2011; 75: 201-203)<br>

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  • Circulation Journal

    Circulation Journal 75 (1), 201-203, 2011

    一般社団法人 日本循環器学会

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