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- Hioki Yoko
- Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry
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- Iinuma Mitsuo
- Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry
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- Kurata Chika
- Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry
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- Ichihashi Yukiko
- Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry
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- Tamura Yasuo
- Department of Pediatric Dentistry, Division of Oral Structure, Function and Development, Asahi University School of Dentistry
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- Kubo Kin-ya
- Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry
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We evaluated whether long-term tooth loss induces functional and morphologic changes in the hippocampus in senescence-accelerated mice (SAMP8) maintained until old age after tooth extraction shortly after tooth eruption. First, to examine whether early tooth loss acts as a stressor, plasma concentration was measured as an index of stress. Plasma corticosterone concentration was significantly higher in old or mature mice with tooth extraction than in the age-matched controls. Plasma corticosterone concentration did not differ between the young tooth extraction and their age-matched control groups. Next, hippocampal function was assessed by evaluating spatial memory performance in the Morris water maze. In the Morris water maze learning and memory trials was significantly slower in the mature or old tooth extraction groups compared with the age-matched controls. There was no significant difference, however, between the young tooth extraction and control groups. Finally, hippocampal neuronal morphology was assessed by counting Nissl-stained cells. The number of hippocampal neurons was significantly reduced in the CA3 region in the mature and old tooth extraction groups compared with their age-matched controls, but there was no significant difference in the CA1-region or dentate gyrus between the mature or old tooth extraction groups and their age-matched controls. In young mice, there was no significant difference in the number of neurons in CA1, CA3, or dentate gyrus region between the tooth extraction and control groups. The findings indicated that tooth extraction after tooth eruption enhances the effects of aging on the hippocampus in mice.
収録刊行物
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- Pediatric Dental Journal
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Pediatric Dental Journal 19 (2), 196-205, 2009
一般社団法人 日本小児歯科学会
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詳細情報 詳細情報について
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- CRID
- 1390282679360185216
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- NII論文ID
- 10027485111
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- NII書誌ID
- AA10809637
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- ISSN
- 18803997
- 09172394
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可