Okara, Soybean Residue, Prevents Obesity in a Diet-Induced Murine Obesity Model
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- MATSUMOTO Kenji
- Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology
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- WATANABE Yutaka
- Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology
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- YOKOYAMA Shin-ichiro
- Gifu Prefectural Research Institute for Bioengineering, Department of Applied Microbiology
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We examined the effect of okara on the prevention of obesity in mice. A modified AIN-76 diet with a high fat content (14.1% of crude fat) was used as a basal diet. Male ICR mice were fed ad libitum with the basal diet or a dried okara-supplemented basal diet (10, 20, or 40%) for 10 weeks. The okara intake dose-dependently suppressed the development of body weight and epididymal white adipose tissue (EWAT), and prevented an increase of plasma lipids, including total cholesterol, LDL cholesterol, and non-esterified fatty acid. The okara intake also prevented steatosis in the liver. Real-time RT-PCR revealed that the okara intake induced down-regulation of the fatty acid synthetase gene and up-regulation of the cholesterol 7 alpha-hydroxylase (CYP7A1) gene in the liver. We also found that the okara intake caused a marked reduction in the expression of leptin and TNF-alpha genes in EWAT. Our results suggest that okara is beneficial in preventing obesity.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 71 (3), 720-727, 2007
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206478886656
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- NII論文ID
- 10027512726
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BD2s7otVKquw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 8696334
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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