Antimicrobiological Activity of Lignan: Effect of Benzylic Oxygen and Stereochemistry of 2,3-Dibenzyl-4-butanolide and 3,4-Dibenzyltetrahydrofuran Lignans on Activity

• AKIYAMA Koichi

  Integrated Center for Sciences, Ehime University

• MARUYAMA Masafumi

  Faculty of Agriculture, Ehime University

• YAMAUCHI Satoshi

  Faculty of Agriculture, Ehime University

• NAKASHIMA Yuki

  Faculty of Agriculture, Ehime University

• NAKATO Tomofumi

  Faculty of Agriculture, Ehime University

• TAGO Ryosuke

  Faculty of Agriculture, Ehime University

• SUGAHARA Takuya

  Faculty of Agriculture, Ehime University

• KISHIDA Taro

  Faculty of Agriculture, Ehime University

• KOBA Yojiro

  Faculty of Agriculture, Ehime University

抄録

The effect of oxidation degree at the benzylic position of 2,3-dibenzyl-4-butanolide and 3,4-dibenzyltetrahydrofuran lignans on the antimicrobiological activity was examined. The highest oxidation degree at the benzylic position of 2,3-dibenzyl-4-butanolide gave the greatest activity, and 3,4-dibenzoyltetrahydrofuran showed the highest antifungal activity. The relationship between stereochemistry and activity was also examined. Both enantiomers of cis-matairesinol were synthesized for the first time, one of the cis-matairesinols showing antibacterial activity.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 71 (7), 1745-1751, 2007

  公益社団法人 日本農芸化学会

キーワード

• antimicrobiological activity
• γ-butyrolactone lignan
• tetrahydrofuran lignan

詳細情報

• CRID: 1390282681457190784
• NII論文ID: 10027516851
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70168
• COI: 1:CAS:528:DC%2BD2sXovFaktLs%3D
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 8840158
• PubMed: 17617715
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8840158
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70168
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可