Tryptophol Induces Death Receptor (DR) 5-Mediated Apoptosis in U937 Cells

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  • INAGAKI Shyuichiro
    Graduate School of Science and Technology, Department of Materials and Life Science, Kumamoto University
  • MORIMURA Shigeru
    Graduate School of Science and Technology, Department of Materials and Life Science, Kumamoto University
  • TANG Yueqin
    Graduate School of Science and Technology, Department of Materials and Life Science, Kumamoto University
  • AKUTAGAWA Hiroshi
    Marumiya Co., Ltd.
  • KIDA Kenji
    Graduate School of Science and Technology, Department of Materials and Life Science, Kumamoto University

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Tryptophol is a natural component isolated from vinegar produced from the boiled extract of black soybean. We have reported that tryptophol induces apoptosis in U937 cells via activation of caspase-8 followed by caspase-3. Tryptophol, however, did not affect human peripheral blood lymphocytes (PBL). In this study, we found that tryptophol enhances formation of a death-inducing signaling complex including death receptor (DR) 5. Cell viability and induction of apoptosis by tryptophol was reduced by transfection with decoy receptor (DcR) 1. These results indicate that tryptophol induces apoptosis through DR5 and that the resistance of PBL to tryptophol-induced apoptosis might be due to competition from DcR1.

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