Award review: F-box proteins that contain sugar-binding domains

• YOSHIDA Yukiko

  Laboratory of Frontier Science, The Tokyo Metropolitan Institute of Medical Science

書誌事項

タイトル別名

• F-Box Proteins That Contain Sugar-Binding Domains

抄録

F-box proteins are the substrate-recognition subunits of the SCF (Skp1-Cul1-F-box protein) complex, which is the largest known class of E3 ubiquitin ligases. They play important roles in ubiquitin-dependent proteolysis in eukaryotes. The human genome contains about 70 genes for F-box proteins, and at least five homologous F-box proteins containing a conserved motif in their C-termini are thought to recognize sugar chain of N-linked glycoproteins. Among theses, Fbs1 and Fbs2 are perhaps involved in the endoplasmic reticulum-associated degradation pathway. In this review, I focus on the in vivo function of Fbs1 and homologous proteins, novel intracellular oligosaccharide recognition molecules involved in the quality control system.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 71 (11), 2623-2631, 2007

  公益社団法人 日本農芸化学会

キーワード

• F-box protein
• high-mannose oligosaccharide
• ubiquitin ligase
• endoplasmic reticulum-associated degradation (ERAD)

詳細情報

• CRID: 1390282681454713088
• NII論文ID: 10027520502
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.70074
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 9284497
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9284497
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.70074
• 本文言語コード: en
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