Effects of Various Amino Acids on Methionine-Induced Hyperhomocysteinemia in Rats

  • FUKADA Shin-ichiro
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • MORITA Tatsuya
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
  • SUGIYAMA Kimio
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University

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Rats were fed diets supplemented with 1% L-methionine with and without 2.5% various amino acids for 7 d to determine what amino acids other than glycine, serine, and cystine can suppress methionine-induced hyperhomocysteinemia. L-Glutamic acid, L-histidine, and L-arginine significantly suppressed methionine-induced enhancement of plasma homocysteine concentrations, but the mechanisms underlying the effect of these amino acids are thought not to be identical.

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