Validation of an Ion Trap Tandem Mass Spectrometric Analysis of Mulberry 1-Deoxynojirimycin in Human Plasma : Application to Pharmacokinetic Studies

Abstract

Mulberry 1-deoxynojirimycin (DNJ) is a potent α-glucosidase inhibitor. Although it is useful for the treatment of diabetes, the human absorption and metabolism of DNJ have never been characterized. We developed a method using hydrophilic interaction chromatography coupled with ion trap tandem mass spectrometry, and found that orally administered DNJ was absorbed into the blood and then excreted into the urine.

Journal

Bioscience, Biotechnology, and Biochemistry  

Bioscience, Biotechnology, and Biochemistry 72(8), 2210-2213, 2008-08-23 

Japan Society for Bioscience, Biotechnology, and Agrochemistry

References:  15

You must have a user ID to see the references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Cited by:  2

You must have a user ID to see the cited references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Codes

  • NII Article ID (NAID) :
    10027531378
  • NII NACSIS-CAT ID (NCID) :
    AA10824164
  • Text Lang :
    ENG
  • Article Type :
    Journal Article
  • ISSN :
    09168451
  • NDL Article ID :
    9628172
  • NDL Source Classification :
    ZR7(科学技術--農林水産--農産) // ZR2(科学技術--生物学--生化学) // ZP1(科学技術--化学・化学工業)
  • NDL Call No. :
    Z53-G223
  • DOI :
    10.1271/bbb.80200
  • Databases :
    CJP  CJPref  NDL  J-STAGE 

Share