Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development in<i>Aspergillus nidulans</i>

• HAGIWARA Daisuke

  New Industry Creation Hatchery Center, Tohoku University

• MIZUNO Takeshi

  Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University

• ABE Keietsu

  New Industry Creation Hatchery Center, Tohoku University Laboratory of Enzymology, Department of Molecular and Cell Biology, Graduate School of Agricultural Sciences, Tohoku University

書誌事項

タイトル別名

• Characterization of NikA Histidine Kinase and Two Response Regulators with Special Reference to Osmotic Adaptation and Asexual Development in Aspergillus nidulans

抄録

Aspergillus nidulans has many histidine-to-aspartate (His-Asp) phosphorelay components, including 15 histidine kinases (HKs), four response regulators (RRs), and a histidine-containing phosphotransfer intermediate (HPt). Of these, NikA (HK) is highly conserved in many filamentous fungi. It has been found that NikA is responsible for the responses of filamentous fungi to fungicides such as iprodione and fludioxonil. Two RRs, SskA and SrrA, are also involved in the fungicide response, providing a typical example of the His-Asp phosphorelay system, in which NikA functions as a sensor upstream of SskA and SrrA in response to fungicides. To gain further insight into the physiological roles of the NikA-SskA/SrrA phosphorelay system, we constructed a pair of ΔnikAΔsskA and ΔnikAΔsrrA double mutants. Here we provide evidence regarding the crucial involvement of the NikA-SskA/SrrA phosphorelay system in both osmotic adaptation and asexual development, including conidia formation. Based on these results, a general insight into the A. nidulans His-Asp phosphorelay network is also discussed.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 73 (7), 1566-1571, 2009

  公益社団法人 日本農芸化学会

キーワード

• <I>Aspergillus nidulans</I>
• histidine-to-aspartate (His-Asp) phosphorelay
• osmotic stress response
• asexual development
• NikA histidine kinase

詳細情報

• CRID: 1390001206479271808
• NII論文ID: 10027543541
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.90063
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10303593
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10303593
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.90063
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
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