Banana Peel Extract Suppressed Prostate Gland Enlargement in Testosterone-Treated Mice

• AKAMINE Kiichiro

  Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology

• KOYAMA Tomoyuki

  Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology

• YAZAWA Kazunaga

  Laboratory of Nutraceuticals and Functional Foods Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology

抄録

A methanol extract of banana peel (BPEx, 200 mg/kg, p.o.) significantly suppressed the regrowth of ventral prostates and seminal vesicles induced by testosterone in castrated mice. Further studies in the androgen-responsive LNCaP human prostate cancer cell line showed that BPEx inhibited dose-dependently testosterone-induced cell growth, while the inhibitory activities of BPEx did not appear against dehydrotestosterone-induced cell growth. These results indicate that methanol extract of banana peel can inhibit 5alpha-reductase and might be useful in the treatment of benign prostate hyperplasia.

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 73 (9), 1911-1914, 2009

  公益社団法人 日本農芸化学会

キーワード

• suppressive effect on benign prostate hyperplasia
• inhibitor of 5alpha-reductase
• banana peel extract
• anti-androgen effect
• mice

詳細情報

• CRID: 1390282681454531072
• NII論文ID: 10027545123
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.80770
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10372141
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10372141
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.80770
• Web Site: https://search.jamas.or.jp/link/ui/2010058088
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可