<i>In Vivo</i>Antitumor and Antioxidative Effects of a Rapeseed Meal Protein Hydrolysate on an S180 Tumor-Bearing Murine Model
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- XUE Zhaohui
- School of Agriculture and Bioengineering, Tianjin University
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- YU Wancong
- Tianjin Institute of Landscape Gardening
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- WU Moucheng
- Department of Food Science and Technology, Huazhong Agricultural University
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- WANG Jiehua
- School of Agriculture and Bioengineering, Tianjin University
書誌事項
- タイトル別名
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- In Vivo Antitumor and Antioxidative Effects of a Rapeseed Meal Protein Hydrolysate on an S180 Tumor-Bearing Murine Model
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The antitumor and antioxidative activities of a rapeseed protein hydrolysate (RSCH) obtained from rapeseed meal were evaluated by using an in vivo S180 tumor-bearing Kunming mice model. Tumor-bearing female mice were given RSCH for 10 at doses of 0, 50, 100, and 150 mg/kg/d by gastric perfusion. RSCH significantly decreased the tumor weight by 44% and 53% in the 100 and 150 mg/kg/d groups, respectively, without causing mortality or growth retardation. The thymus and spleen indices (organ weight relative to body weight) were increased significantly in the 150 mg/kg/d group. The phagocytic capability of coeliac macrophages and delayed-type hypersensitivity (DTH) were significantly increased in tumor-bearing mice treated with RSCH at 150 mg/kg/d. RSCH administration also enhanced the superoxide dismutase activity and reduced the serum level of thiobarbituric acid reactive substances. Our results show that an oral RSCH administration had an antitumor protective effect and may improve immune function by reducing free radical formation and oxidative stress in a murine model.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 73 (11), 2412-2415, 2009
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206480651904
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- NII論文ID
- 10027547590
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10458892
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可