Studies of the Structure-Activity Relationships of Peptides and Proteins Involved in Growth and Development Based on Their Three-Dimensional Structures

  • NAGATA Koji
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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Peptides and proteins with similar amino acid sequences can have different biological functions. Knowledge of their three-dimensional molecular structures is critically important in identifying their functional determinants. In this review, I describe the results of our and other groups’ structure-based functional characterization of insect insulin-like peptides, a crustacean hyperglycemic hormone-family peptide, a mammalian epidermal growth factor-family protein, and an intracellular signaling domain that recognizes proline-rich sequence.

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