Identification and Classification of a Two-Component System Based on Domain Structures in Bacteria and Differences in Domain Structure between Gram-Positive and Gram-Negative Bacteria
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- KIM Sangwan
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University
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- HIRAKAWA Hideki
- Laboratory for Plant Genome Informatics, Department of Plant Genome Research, Kazusa DNA Research Institute
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- MUTA Shigeru
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Graduate School of Systems Life Sciences, Kyushu University
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- KUHARA Satoru
- Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University Graduate School of Systems Life Sciences, Kyushu University
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Genome sequencing has revealed many pairs of proteins termed two-component systems (TCSs) in bacteria. Each pair consists of a sensor or histidine kinase (HK) and an effector or response regulator (RR). The HK is usually a membrane-spanning protein that senses specific environmental parameters and communicates this information to the cytoplasmic RR protein through phosphotransfer reactions to cope with a variety of environmental stresses, including osmotic pressure, nitrogen lack, phosphoric acid lack, and the presence of oxygen. Furthermore, some proteins have been identified as hybrid kinases composed of HK and RR. We identified the domain structures of 360 bacteria and 43 archaea by domain search against the PFAM database using HMMER. We then classified 8,573 HK, 10,807 RR, and 2,477 hybrid kinases. In addition, we identified specific domains among phylogenic clusters based on differences in domain structure of TCS genes applying the Signal-to-Noise ratio.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 74 (4), 716-720, 2010
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206478091392
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- NII論文ID
- 10027553507
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 10656375
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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