Inhibition of Plasma Hyaluronan-Binding Protein Autoactivation by Laccaic Acid

• SEKIDO Chikako

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

• NISHIMURA Naoko

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

• TAKAI Masayuki

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

• HASUMI Keiji

  Department of Applied Biological Science, Tokyo University of Agriculture and Technology

抄録

Plasma hyaluronan-binding protein (PHBP) is a serine protease implicated in proteolysis under inflammatory conditions. We identified laccaic acid, a widely used food coloring from scale insects, as a potent inhibitor of the protease in terms of both autoactivation of the PHBP proenzyme (IC₅₀ = 0.35–0.55 μg/ml) and the catalytic activity of the active enzyme (IC₅₀ = 1.1 μg/ml).

収録刊行物

• Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ

  Ｂｉｏｓｃｉｅｎｃｅ，　Ｂｉｏｔｅｃｈｎｏｌｏｇｙ，　ａｎｄ　Ｂｉｏｃｈｅｍｉｓｔｒｙ 74 (11), 2320-2322, 2010

  公益社団法人 日本農芸化学会

キーワード

• lac dye
• laccaic acid
• plasma hyaluronan-binding protein (PHBP)
• factor VII activating protease (FSAP)

詳細情報

• CRID: 1390282681456111616
• NII論文ID: 10027561853
• NII書誌ID: AA10824164
• DOI: 10.1271/bbb.100373
• ISSN: 13476947
• ISSN: 09168451
• NDL書誌ID: 10900012
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10900012
• Web Site: http://www.tandfonline.com/doi/pdf/10.1271/bbb.100373
• 本文言語コード: en
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