Involvement of Prostaglandins in Suppression of Gonadotropin-Releasing Hormone Pulse Generator Activity by Tumor Necrosis Factor-α
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- YOO Mi-Jeong
- Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo 113, Japan
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- NISHIHARA Masugi
- Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo 113, Japan
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- TAKAHASHI Michio
- Department of Veterinary Physiology, Veterinary Medical Science, The University of Tokyo, Tokyo 113, Japan
書誌事項
- タイトル別名
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- Involvement of Prostaglandins in Suppression of Gonadotropin-Releasing Hormone Pulse Generator Activity by Tumor Necrosis Factor-.ALPHA..
- Involvement of Prostaglandins in Suppre
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Previous research from our laboratory has shown that tumor necrosis factor (TNF)-α, administered either intravenously (iv) or intracerebroventricularly (icv), suppressed the electrical activity of hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator in the rat. The present study was conducted to elucidate the possible roles of prostaglandins (PGs) and corticotropin-releasing hormone (CRH) in mediating the effect of TNF-α. Ovariectomized rats were fitted with chronically implanted electrode arrays in the mediobasal hypothalamus, and multiunit activity (MUA) was recorded under an unrestrained condition. Blood samples were withdrawn every 6 min through an indwelling atrial catheter for the determination of serum luteinizing hormone (LH) concentrations. During a pretreatment control period, characteristic increases (volleys) in MUA coincident with the initiation of each LH pulse were recorded. Indomethacin (1 mg/100 g BW, iv), a cyclooxygenase inhibitor, blocked the decrease in the frequency of MUA volleys induced by iv (1 μg) or icv (50 ng) injection of TNF-α. In contrast, icv injection of the CRH receptor antagonist (α-helical CRH, 100 μg) failed to block the suppressive effect of TNF-α on volley frequency. Neither indomethacin nor α-helical CRH alone affected the recurrence of MUA volleys. These results suggest that TNF-α suppresses GnRH pulse generator activity at least partially through PG-, but not CRH-, dependent mechanisms.
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 43 (2), 181-187, 1997
公益社団法人 日本繁殖生物学会
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詳細情報 詳細情報について
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- CRID
- 1390001206333524480
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- NII論文ID
- 10027567245
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- NII書誌ID
- AA10936678
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- COI
- 1:CAS:528:DyaK2sXltlWkurc%3D
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 4240402
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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