Elevation of Adipsin, a Complement Activating Factor, in the Mouse Placenta During Spontaneous Abortion

• TAKESHITA Ai

  Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University

• KONDO Tomohiro

  Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University

• OKADA Toshiya

  Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University

• KUSAKABE Ken Takeshi

  Laboratory of Laboratory Animal Science, Department of Integrated Structural Biosciences, Division of Veterinary Science, Graduate School of Life and Environmental Biosciences, Osaka Prefecture University

抄録

The complement system is thought to be precisely regulated during pregnancy. We have examined specific gene profiles in mouse placentas causing spontaneous abortion and found notable up-regulation of adipsin, a complement activating factor. The aim of the present study was to determine the basic kinetics and localization of adipsin in the placenta and the difference in complement activity between normal placentas and placentas of abortuses. Normal and spontaneously absorbed implantation sites obtained from naturally-mated mouse uteri on days 10.5 and 14.5 of pregnancy were processed for histologic studies and protein purification. Adipsin immunoreaction was detected at the decidua basalis in normal placentas and additionally at the placental labyrinth in the absorbed placentas. The quantity of adipsin was increased in the absorbed placentas compared with the normal placentas. In concert with the increase in adipsin, the amounts of complement component 3 and degradation products were elevated and complemental activity was up-regulated in the absorbed placenta. These findings suggest that local expression of adipsin has a reproductive effect at the feto-maternal interface and possibly plays a role in spontaneous abortion.<br>

収録刊行物

• Journal of Reproduction and Development

  Journal of Reproduction and Development 56 (5), 508-514, 2010

  公益社団法人 日本繁殖生物学会

キーワード

• Adipsin
• C3
• Complement
• Mouse placenta
• Spontaneous abortion

詳細情報

• CRID: 1390282681313184128
• NII論文ID: 10027571785
• NII書誌ID: AA10936678
• DOI: 10.1262/jrd.10-036k
• ISSN: 13484400
• ISSN: 09168818
• NDL書誌ID: 10867079
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10867079
• Web Site: http://www.jstage.jst.go.jp/article/jrd/56/5/56_10-036K/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011238258
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可