精子ファクターPLCζと卵活性化

• 黒田 恵司

  順天堂大学医学部産科婦人科学教室

書誌事項

タイトル別名

• Sperm Factor, PLC.ZETA., and Egg Activation
• セイシ ファクター PLC ゼータ ト ラン カッセイカ
• Sperm Factor, PLC , and Egg Activation

抄録

At fertilization, mammalian eggs show repetitive transient [Ca²⁺]_i rises each of which is due to Ca²⁺ release from the endoplasmic reticulum through inositol 1,4,5-trisphosphate (IP₃) receptors. During fertilization, a factor from the sperm, the sperm factor, is released into the oocyte and induces a long-lasting series of Ca²⁺ spikes (Ca²⁺ oscillations) that are required for egg activation. IP3-producing enzyme phospholipase C zeta (PLCζ) is a strong candidate for the sperm factor. The Ca²⁺ spikes initiate the extrusion of cortical granules that block the entry of other sperm. At the same time, maturation (M-phase) promoting factor (MPF) is inactivated by the Ca²⁺ oscillations, resulting in exit from metaphase II arrest. Meiosis resumes with formation of the second polar body and complete meiotic division, one-cell embryos with the male and female pronuclei attain the first cleavage division through nuclear envelope breakdown.<br>

収録刊行物

• 日本哺乳動物卵子学会誌

  日本哺乳動物卵子学会誌 27 (4), 198-203, 2010

  日本卵子学会

キーワード

• 卵活性化
• ホスフォリパーゼCゼータ
• Ca²⁺オシレーション
• 精子ファクター

詳細情報

• CRID: 1390282679314667136
• NII論文ID: 10027595437
• NII書誌ID: AN10548943
• DOI: 10.1274/jmor.27.198
• ISSN: 13475878
• ISSN: 13417738
• NDL書誌ID: 10893974
• Web Site: https://agriknowledge.affrc.go.jp/RN/2010800298
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10893974
• Web Site: https://search.jamas.or.jp/link/ui/2011036953
• 本文言語コード: en
• データソース種別:
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  • IRDB
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