書誌事項
- タイトル別名
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- Vascular Endothelial Growth Factor (VEGF) Expression in Contused Brain Tissue: The Role of Angiogenesis after Traumatic Brain Injury in Rats
- ラット ノウ ザショウ モデル ニ オケル VEGF ノ ハツゲン ト ソノ ヤクワリ
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抄録
Vascular Endothelial Growth Factor (VEGF) is a protein associated with angiogenesis and a potent vascular permeability factor. This study was undertaken to assess the neurological and histological roles of VEGF after TBI (Traumatic Brain Injury) in a rat model of cerebral contusion. We examined the time course of VEGF expression, BBB (Blood Brain Barrier) disruption, and brain edema after traumatic brain injury. The necrosis volume and motor performance were measured to determine tissue repair and functional recovery after the brain injury. The contusion necrosis volume was aggravated at 21 days after the injury (115.0 ± 14.3 mm³ vs. 137.3 ± 21.1 mm³, p < 0.05) and motor performance, which was evaluated at 1, 3, 7, 14, 21 days after the injury by Rota rod test, recovered less in the bevacizumab (VEGF antibody) treated group (78.4 ± 9.8% vs. 103.6 ± 7.7%, p < 0.05). We conclude that VEGF may have therapeutic potential for tissue repair and functional recovery after the injury, via angiogenesis.
収録刊行物
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- 日大医学雑誌
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日大医学雑誌 69 (5), 298-303, 2010
日本大学医学会
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詳細情報 詳細情報について
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- CRID
- 1390001206432999808
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- NII論文ID
- 130004548825
- 10027718183
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- NII書誌ID
- AN0018408X
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- ISSN
- 18840779
- 00290424
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- NDL書誌ID
- 10893885
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
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- 抄録ライセンスフラグ
- 使用不可