Identification of susceptibility genes for Kawasaki disease

• ONOUCHI Yoshihiro

  Laboratory for Cardiovascular disease, Center for Genomic Medicine, RIKEN

Bibliographic Information

Other Title

• 川崎病の罹患感受性遺伝子の同定

Abstract

  Kawasaki disease is an acute febrile illness of infants and children with unknown etiology. Coronary artery lesions occurring in 20-25% of untreated patients of KD has made KD a leading cause of acquired heart diseases of childhood in developed countries. High prevalence in East Asian countries is one of the epidemiological features of KD and has suggested genetic factors underlying the disease pathogenesis. We tried to identify genetic variants relevant to KD susceptibility by sibpair linkage study and linkage diseuilibrium mapping with SNPs and found that inositol 1,4,5-trisphosphate 3-kianse C gene is a susceptibility gene for KD. We also found the negative regulatory role of ITPKC in TCR signaling and the mechanism by which the responsible SNP in intron 1 of the gene affects transcripts level of ITPKC. Our findings highlighted the importance of Ca²⁺/NFAT pathway in the pathogenesis of KD and shed light on the possibility of immuno-suppressants targeting the pathway as a therapeutic strategy for KD.<br>

Journal

• Japanese Journal of Clinical Immunology

  Japanese Journal of Clinical Immunology 33 (2), 73-80, 2010

  The Japan Society for Clinical Immunology

Keywords

• Kawasaki disease
• susceptibility gene
• SNP

Details

• CRID: 1390001204648696064
• NII Article ID: 10027753409
• NII Book ID: AN00357971
• DOI: 10.2177/jsci.33.73
• ISSN: 13497413
• ISSN: 09114300
• Web Site: http://www.jstage.jst.go.jp/article/jsci/33/2/33_2_73/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010226283
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed