上咽頭癌に対する化学放射線交替療法の治療成績

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  • Clinical Results of Alternating Chemoradiotherapy for Nasopharyngeal Cancer
  • ジョウ イントウガン ニ タイスル カガク ホウシャセン コウタイ リョウホウ ノ チリョウ セイセキ

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The lack of definitive symptoms makes nasopharyngeal cancer difficult to diagnose early. Anatomically, nasopharyngeal cancer surgery is also very difficult. Nasopharyngeal cancer is classified histologically as undifferentiated or poorly differentiated, and is sensitive to radiotherapy and chemotherapy. The alternative chemoradiation protocol we developed cosists of 2-day CDDP (50 mg/m2/day), 5-day 5FU (800 mg/m2/day), and radiotherapy of 66 Gy in 36 fractions. Using this protocol, we have treated 9 subjects. Full-course three-cycle chemotherapy has been done in 89. Overall 5-year survival and disease-specific cumulative 5-year survival were both 100.0%, with 5-year disease-free survival 71.1%. Recurrence involved a neck lymph node in one subject and distant metastases in two. This treatment thus appears very useful, despite severe mucositis in 66.6% making long-term oral intake difficult and requiring long-term hospitalization. The next goal is thus reducing the incidence of mucositis complications.<br>

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