Association between Bone Mineral Density and Arterial Stiffness in Hypertensive Patients

• Masugata Hisashi

  Department of Integrated Medicine, Kagawa University

• Senda Shoichi

  Department of Integrated Medicine, Kagawa University

• Inukai Michio

  Department of Integrated Medicine, Kagawa University

• Murao Koji

  Division of Endocrinology and Metabolism, Department of Internal medicine, Kagawa University

• Hosomi Naohisa

  Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences

• Iwado Yasuyoshi

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

• Noma Takahisa

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

• Kohno Masakazu

  Department of Cardiorenal and Cerebrovascular Medicine, Kagawa University

• Miyatake Nobuyuki

  Department of Hygiene, Faculty of Medicine, Kagawa University

• Himoto Takashi

  Department of Integrated Medicine, Kagawa University

• Goda Fuminori

  Department of Integrated Medicine, Kagawa University

抄録

Hypertension and osteoporosis are two common diseases in the elderly population. Recently, reduced bone mineral density has been found in hypertensive patients compared with healthy controls. Reduced bone mineral density is associated with increased arterial stiffness in chronic dialysis patients and healthy postmenopausal women. However, relationships between bone mineral density and arterial stiffness in hypertensive patients have not been fully assessed. We examined the relationships between bone mineral density and both arterial stiffness and nutritional status in 52 hypertensive patients (27 male and 25 female subjects; mean age 71 ± 8 years) who had been treated with antihypertensive drugs for at least one year. The bone mineral density of the calcaneus was measured with a quantitative ultrasound measurement device, and the stiffness index was determined as a parameter of the bone mineral density. We measured the cardio-ankle vascular index (CAVI) to assess arterial stiffness and used the serum albumin to assess nutritional status. Increased arterial stiffness as assessed with CAVI is associated with reduced bone mineral density (r = −0.289, p = 0.038). However, the correlation between CAVI and bone mineral density is not as strong as the correlation between serum albumin and bone mineral density (r = 0.501, p < 0.001). In conclusion, nutritional status is an important indicator of bone mineral density in hypertensive patients. Moreover, increased arterial stiffness is associated with reduced bone mineral density in hypertensive patients. Therefore, hypertensive patients with increased arterial stiffness may have a high risk of bone fracture due to osteoporosis.

収録刊行物

• The Tohoku Journal of Experimental Medicine

  The Tohoku Journal of Experimental Medicine 223 (2), 85-90, 2011

  東北ジャーナル刊行会

キーワード

• hypertension
• bone mineral density
• arterial stiffness
• cardio-ankle vascular index

詳細情報

• CRID: 1390001204244136704
• NII論文ID: 130004459879
• NII論文ID: 10027806773
• NII書誌ID: AA00863920
• DOI: 10.1620/tjem.223.85
• ISSN: 13493329
• ISSN: 00408727
• Web Site: http://www.jstage.jst.go.jp/article/tjem/223/2/223_2_85/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011323375
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可