書誌事項
- タイトル別名
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- Clinical study of 10 cases of pemphigus vulgaris initially occurring in the oral mucosa
- コウクウ ネンマク ニ ショハツ シタ ジンジョウセイ テンポウソウ 10レイ ノ リンショウテキ ケントウ
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We report our clinical experience with 10 cases of pemphigus vulgaris(PV)initially arising in the oral mucosa. The patients were 3 males and 7 females, with a mean age of 47.4 years. The patients were classified into a mucosal type(PV-M)group or a mucocutaneous type(PV-MC)group according to their serum levels of antidesmoglein(Dsg)-1 and Dsg-3 autoantibodies. Their clinical features and treatment outcomes were assessed.<br>The most commonly affected sites in the oral cavity were the gingiva and buccal mucosa in both the PV-M and PV-MC groups. Skin involvement was frequent in the PV-MC group(80 %), but not in the PV-M group(40 %).<br>Systemic steroid therapy was given to all of the patients, and both the oral and skin lesions completely disappeared within 1 month. Seven patients had relapses after tapering of the steroid dosage to the maintenance level.All patients with relapse had mucosal lesions in the oral cavity.<br>We examined the serum levels of autoantibodies to Dsg-1 and Dsg-3 and evaluated the correlation between the serum autoantibody level and severity of disease. Patients with severe oral symptoms had higher serum levels of Dsg autoantibodies. However, the severity of the skin lesions was not strongly related to the serum autoantibody levels.
収録刊行物
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- 日本口腔外科学会雑誌
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日本口腔外科学会雑誌 56 (3), 189-193, 2010
社団法人 日本口腔外科学会
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詳細情報 詳細情報について
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- CRID
- 1390282681507750912
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- NII論文ID
- 10027842532
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- NII書誌ID
- AN00189163
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- ISSN
- 21861579
- 00215163
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- NDL書誌ID
- 10637666
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- 使用不可