Development and Characterization of a Congenic Strain Carrying Pbwg12, a Growth QTL on Mouse Chromosome 12

• ISHIKAWA Akira

  Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University

• LI Chun

  Laboratory of Animal Genetics, Division of Applied Genetics and Physiology, Graduate School of Bioagricultural Sciences, Nagoya University

抄録

In previous genome-wide QTL studies, Pbwg12 on mouse chromosome 12 was discovered in a gene pool of wild Mus musculus castaneus mice. Pbwg12 does not have a main effect but has an epistatic interaction effect on body weight after birth. In this study, we developed a congenic strain, named B6.Cg-Pbwg12, with an approximately 59-Mb wild-derived genomic region harboring Pbwg12, by recurrent backcrossing to C57BL/6J. A phenotypic comparison between B6.Cg-Pbwg12 and C57BL/6J revealed that Pbwg12 does not have any main effects on body weight at 1-10 weeks of age but has a main effect on body weight gain at 6-10 weeks. A new QTL with a male-specific effect on kidney weight was discovered within the introgressed region.<br>

収録刊行物

• Experimental Animals

  Experimental Animals 59 (1), 109-113, 2010

  公益社団法人 日本実験動物学会

キーワード

• congenic strain
• growth QTL
• mouse

詳細情報

• CRID: 1390001205044707200
• NII論文ID: 10027852777
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.59.109
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 10811140
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10811140
• Web Site: http://www.jstage.jst.go.jp/article/expanim/59/1/59_1_109/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010166949
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可