High Molecular Weight Lectin Isolated from the Mucus of the Giant African Snail<i>Achatina fulica</i>

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  • ITO Shigeru
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University
  • SHIMIZU Masahiro
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University
  • NAGATSUKA Maki
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University
  • KITAJIMA Seiji
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University
  • HONDA Michiyo
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University
  • TSUCHIYA Takahide
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University
  • KANZAWA Nobuyuki
    Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University

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  • High Molecular Weight Lectin Isolated from the Mucus of the Giant African Snail Achatina fulica

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To understand better the host defense mechanisms of mollusks against pathogens, we examined the anti-microbial activity of mucus from the giant African snail Achatina fulica. Hemagglutination activity of the mucus secreted by the integument of snails inoculated with Escherichia coli was observed to increase and to cause hemagglutination of rabbit red blood cells. Purification of the snail mucus lectin by sequential column chromatography revealed that the relative molecular mass of the lectin was 350 kDa. The hemagglutination activity of the lectin was Ca2+-dependent and was inhibited by galactose. Growth arrest tests showed that the lectin did not inhibit bacterial growth, but did induce agglutination of gram-positive and gram-negative bacteria. Tissue distribution analyses using a polyclonal antibody revealed that the lectin was expressed in the tissues of the mantle collar. The lectin isolated from the mucus of the snail appeared to contribute to its innate immunity.

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