Micro-CT based quantitative evaluation of in vivo bone regeneration with collagen-based biomaterials

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  • ATA Fumio
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry
  • KATAOKA Yu
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry
  • TAMAKI Yukimichi
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry
  • YAMAKI Koichi
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry
  • MIYAZAKI Takashi
    Department of Oral Biomaterials and Technology, Showa University School of Dentistry

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  • Micro-CT Based Quantitative Evaluation of <i>In Vivo</i> Bone Regeneration with Collagen-based Biomaterials

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Increase of biological stability primarily determines the bone regeneration potential of the collagenbased biomaterials. Addition of calcium phosphates has been an option in reinforcement of the collagen-based biomaterials. Nano-scale β-TCP allows higher self assembly and cross-linking with collagen molecules whereas the hydroxyapatite is not suitable starting material to create bone-like collagen composite without toxic cross-linking agents. The present study investigates in vivo bone regeneration potential of two collagen-based biomaterials, namely, β-TCP/collagen composite and collagen alone. The collagen alone did not show sufficient scaffold properties. Since β-TCP/collagen composite showed better scaffold property in comparison with collagen alone, biological stability is an important determinant of collagen-based biomaterials.

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