The Effect of L-citrulline Ingestion on ECG QT Interval and Autonomic Nervous System Activity

• Kameda Naoko

  Department of Food and Nutrition Science, Sagami Women's Junior College

• Okigawa Tatsuya

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

• Kimura Tetsuya

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

• Fujibayashi Mami

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

• Asada Tomoko

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

• Kinoshita Ryohei

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

• Baba Sadayuki

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

• Morita Masahiko

  Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd.

• Morishita Koji

  Healthcare Products Development Center, Kyowa Hakko Bio Co., Ltd.

• Moritani Toshio

  Laboratory of Applied Physiology, Graduate School of Human and Environmental Studies, Kyoto University

抄録

The purpose of this study was to investigate the effect of L-citrulline ingestion on ECG QT interval. To accomplish this purpose, nine male subjects (age: 23.4±0.5 years, weight: 57.7±5.6 kg) participated, who had no history of cardiovascular or respiratory function disorders. Each subject performed two tests (L-citrulline and placebo ingestion) on a separate day. ECG was taken before, and 60 min and 90 min after L-citrulline ingestion. The heart-rate-corrected QT interval (QTc) decreased significantly 60 min (p=0.0004) and 90 min (p=0.011) after L-citrulline ingestion. However, there were no significant changes after placebo ingestion. In addition, the interaction between L-citrulline ingestion and placebo was significant (two-way ANOVA: interaction, p=0.010). Our major finding was that L-citrulline ingestion decreases the QT interval in healthy subjects. This result suggests that transient L-citrulline ingestion may shorten the time required to complete myocardial depolarization and repolarization.

収録刊行物

• Journal of PHYSIOLOGICAL ANTHROPOLOGY

  Journal of PHYSIOLOGICAL ANTHROPOLOGY 30 (2), 41-45, 2011

  日本生理人類学会

キーワード

• QTc interval
• pulsatility index
• L-citrulline
• Nitric oxide

詳細情報

• CRID: 1390001205254036608
• NII論文ID: 10028100126
• NII書誌ID: AA12113950
• DOI: 10.2114/jpa2.30.41
• ISSN: 18806805
• ISSN: 18806791
• Web Site: https://search.jamas.or.jp/link/ui/2012030745
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可