Pulmonary Toxicity in Mice by 2- and 13-week Inhalation Exposures to Indium-tin Oxide and Indium Oxide Aerosols
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- Nagano Kasuke
- Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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- Nishizawa Tomoshi
- Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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- Eitaki Yoko
- Occupational Health Research and Development Center, Japan Industrial Safety and Health Association
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- Ohnishi Makoto
- Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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- Noguchi Tadashi
- Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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- Arito Heihachiro
- Japan Bioassay Research Center, Japan Industrial Safety and Health Association
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- Fukushima Shoji
- Japan Bioassay Research Center, Japan Industrial Safety and Health Association
Bibliographic Information
- Other Title
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- Brief report: Pulmonary toxicity in mice by 2- and 13-week inhalation exposures to indium-tin oxide and indium oxide aerosols
- Pulmonary Toxicity in Mice by 2‐ and 13‐week Inhalation Exposures to Indium‐tin Oxide and Indium Oxide Aerosols
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Abstract
Objectives: Inhalation toxicities of indium-tin oxide (ITO) and indium oxide (IO) in mice were characterized in comparison with those previously reported in rats. Methods: B6C3F1 mice of both sexes were exposed by inhalation to ITO or IO aerosol for 6 h/day, 5 day/wk for 2 wk at 0, 0.1, 1, 10 or 100 mg/m3 or 13 wk at 0, 0.1or 1 mg/m3. Results: ITO and IO particles were deposited in the lung, mediastinal lymph node (MLN) and nasal-associated lymphoid tissue. Alveolar proteinosis, infiltrations of alveolar macrophages and inflammatory cells and increased lung weight were induced by 2- and 13-week exposures to ITO and IO, while alveolar epithelial hyperplasia occurred only in the 2-week exposures. Thickened pleural wall, hyperplastic MLN, extramedullary hematopoiesis in the spleen and increased levels of erythrocyte parameters were induced by 13-week exposure to ITO. The ITO- and IO-induced pulmonary lesions were milder in mice than those previously reported in rats, and the fibrotic lesions were different between these two species. Indium levels in the lung and pooled blood were analyzed in the mice exposed to ITO and IO for 13 wk. In the 13-week inhalation exposure of mice to ITO, alveolar proteinosis and significantly increased lung weight were induced at the same exposure concentration as the current threshold limit value for indium and its compounds.<br>
Journal
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- Journal of Occupational Health
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Journal of Occupational Health 53 (3), 234-239, 2011
Japan Society for Occupational Health
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Keywords
Details 詳細情報について
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- CRID
- 1390001204456729216
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- NII Article ID
- 10028109551
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- NII Book ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL BIB ID
- 11096512
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed