The Influence of Gender- and Age-related Differences in the Radiosensitivity of Hematopoietic Progenitor Cells Detected in Steady-state Human Peripheral Blood

• KATO Kengo

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

• KUWABARA Mikinori

  Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University

• KASHIWAKURA Ikuo

  Department of Radiological Life Sciences, Hirosaki University Graduate School of Health Sciences

抄録

To investigate the importance of gender and aging on the individual radiosensitivity of lineage-committed myeloid hematopoietic stem/progenitor cells (HSPCs) detected in mononuclear cells (MNCs) of steady-state human peripheral blood (PB), the clonogenic survival of HPCs, including colony-forming unit-granulocyte macrophage; burst-forming unit-erythroid; colony-forming unit-granulocyte-erythroid-macrophage-megakaryocyte cells derived from MNCs exposed to 0.5 Gy and 2 Gy X-irradiation were estimated. MNCs were prepared from the buffy-coats of 59 healthy individual blood donors. The results showed that large individual differences exist in the number of HSPCs, as well as in the surviving fraction of cells. Furthermore, the number of progenitor cells strongly correlated with their surviving fraction, suggesting that the radiosensitivity of hematopoietic progenitor cells decreases with the number of cells in the 10⁵ cells population. A statistically significant negative correlation was observed between the surviving fraction observed at a dose of 0.5 Gy and the age of an individual, however, none of these correlations were observed after 2 Gy irradiation. No statistically significant difference was observed in individual radiosensitivity between males and females at either radiation dose. The present results indicated a correlation between the individual responsiveness of HSPCs to ionizing irradiation, especially to low dose irradiation, and aging.

収録刊行物

• Journal of Radiation Research

  Journal of Radiation Research 52 (3), 293-299, 2011

  Journal of Radiation Research 編集委員会

キーワード

• Hematopoietic progenitor cells
• Peripheral blood
• Radiosensitivity
• Gender
• Age

詳細情報

• CRID: 1390001205216058880
• NII論文ID: 10028111162
• NII書誌ID: AA00705792
• DOI: 10.1269/jrr.10142
• ISSN: 13499157
• ISSN: 04493060
• NDL書誌ID: 11088936
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11088936
• Web Site: http://academic.oup.com/jrr/article-pdf/52/3/293/2703148/jrr-52-293.pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012122535
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可