Long-Term Follow-up of Patients With Isolated Left Ventricular Noncompaction - Role of Electrocardiography in Predicting Poor Outcome -

• Steffel Jan

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Hürlimann David

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Namdar Mehdi

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Despotovic Dragan

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Kobza Richard

  Division of Cardiology, Luzerner Kantonsspital

• Wolber Thomas

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Holzmeister Johannes

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Haegeli Laurent

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Brunckhorst Corinna

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Lüscher Thomas F.

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Jenni Rolf

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich

• Duru Firat

  Clinic for Cardiology, Cardiovascular Center, University Hospital Zurich Center for Integrative Human Physiology, University of Zurich

書誌事項

タイトル別名

• – Role of Electrocardiography in Predicting Poor Outcome –

抄録

Background: Abnormal baseline electrocardiograms (ECGs) are common in patients with isolated left ventricular noncompaction (IVNC). Whether certain electrocardiographic parameters are associated with a poor clinical outcome, however, remains elusive. The present study was therefore designed to comprehensively assess the predictive value of baseline ECG findings in patients newly diagnosed with IVNC. Methods and Results: 74 patients diagnosed with IVNC were included in the analysis. During follow-up, 8 patients (11%) died of a cardiovascular cause or underwent heart transplantation (primary outcome measure). On univariate analysis, several variables, including repolarization abnormalities (ST segment elevation/depression, T-wave inversion) in the inferior leads (5-year estimator: 67.1±10.7% vs. 98±2.2%; P=0.001), an increase in PQ- (hazard ratio (HR) 1.032, P=0.004) and QTc-duration (HR 1.037, P=0.001), were predictive of cardiovascular death or heart transplantation. On multivariate analysis, only PQ- and QTc-duration and the presence of repolarization abnormalities in the inferior leads remained significantly predictive of a poor outcome. Conclusions: PQ duration, QTc duration, and repolarization abnormalities in the inferior leads are independently predictive of a poor prognosis in IVNC. Further prospective studies are required to conclusively investigate the usefulness of baseline ECG parameters for risk stratification in patients with IVNC. (Circ J 2011; 75: 1728-1734)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 75 (7), 1728-1734, 2011

  一般社団法人 日本循環器学会

キーワード

• Electrocardiography
• Noncompaction cardiomyopathy
• Outcome predictors

詳細情報

• CRID: 1390001205105869056
• NII論文ID: 10029126937
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-10-1217
• ISSN: 13474820
• ISSN: 13469843
• Web Site: http://www.jstage.jst.go.jp/article/circj/75/7/75_CJ-10-1217/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2012001403
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可