Expression of Heme Oxygenase‐1 in the Lungs of Rats Exposed to Potassium Octatitanate Whiskers

• Obata Yasuko

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Morimoto Yasuo

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Hirohashi Masami

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Ogami Akira

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Oyabu Takako

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Myojo Toshihiko

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Kawanami Shoko

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Horie Seichi

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Nagatomo Hiroko

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Murakami Masahiro

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• Tanaka Isamu

  Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

書誌事項

タイトル別名

• Expression of Heme Oxygenase-1 in the Lungs of Rats Exposed to Potassium Octatitanate Whiskers

抄録

Objectives: Oxidative stress is thought to be the pathogenesis of pulmonary fibrosis induced by asbestos, and heme oxygenase-1 (HO-1) protects lung tissue against oxidative stress. We hypothesized that HO-1 is also associated with oxidative lung injury caused by exposure to potassium octatitanate whiskers (PT1), which is one of the asbestos substitutes. Methods: Male Wistar rats were administered 1 mg or 2 mg PT1 suspended in saline by a single intratracheal instillation and were sacrificed after recovery for 3 days, 1 wk, 1 mo, 3 mo or 6 mo. Gene expression of HO-1 protein and mRNA and immunostaining were investigated in rat lungs. Results: HO-1 protein expression was increased from 3 days to 1 mo and at 6 mo in the 1 or 2 mg PT1-exposed groups, and the gene expression of HO-1 mRNA was also increased at 3 days and from 1 mo to 6 mo. HO-1-positive cells were mainly found in the alveolar macrophages and the bronchial epithelial cells in immunostaining. Conclusions: These findings suggest that HO-1 is involved in lung damage caused by PT1.<br>

収録刊行物

• ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ

  ｊｏｕｒｎａｌ　ｏｆ　Ｏｃｃｕｐａｔｉｏｎａｌ　Ｈｅａｌｔｈ 53 (4), 267-273, 2011

  公益社団法人 日本産業衛生学会

キーワード

• Heme oxygenase-1 (HO-1)
• Intratracheal instillation
• Oxidative stress
• Potassium octatitanate whisker (PT1)

詳細情報

• CRID: 1390282679431647232
• NII論文ID: 10029139731
• NII論文ID: 130004447544
• NII書誌ID: AA11090645
• DOI: 10.1539/joh.l10056
• ISSN: 13489585
• ISSN: 13419145
• NDL書誌ID: 11183680
• PubMed: 21670561
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I11183680
• Web Site: https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1539%2Fjoh.L10056
• Web Site: https://onlinelibrary.wiley.com/doi/pdf/10.1539/joh.L10056
• Web Site: https://search.jamas.or.jp/link/ui/2012074540
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
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