進行肝細胞癌に対する肝動注化学療法 : 114例の検討  [in Japanese] Hepatic arterial fusion chemotherapy in patients with advanced hepatocellular carcinoma : analysis of 114 cases  [in Japanese]

    • 浦山 直樹 URAYAMA Naoki
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 山崎 隆弘 YAMASAKI Takahiro
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 播磨 陽平 [他] HARIMA Yohei
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine

    • 佐伯 一成 SAEKI Issei
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 在津 潤一 ZAITSU Junichi
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 浜辺 崇衣 HAMABE Satoe
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine

    • 原野 恵 HARANO Megumi
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 戒能 聖治 KAINO Seiji
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine

    • 内田 耕一 UCHIDA Kouichi
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 寺井 崇二 TERAI Shuji
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine
    • 坂井田 功 SAKAIDA Isao
    • 山口大学大学院医学系研究科消化器病態内科学 Department of Gastroenterology and Hepatology, Yamaguchi University Graduate School of Medicine

Access this Article

  • J-STAGE

  • CrossRef

Search this Article

Abstract

進行肝細胞癌に対する肝動注化学療法の奏効ならびに予後に寄与する因子を検討した.当科での過去12年間に肝動注化学療法を施行した114例を対象とした.動注レジメンとしては,Low-dose FP療法(cisplatin,5-fluorouracil)をベースとし,Low-dose FPは,15例(13%),Low-dose FP+leucovorin/isovorinは,71例(62%),およびLow-dose FP+isovorin+interferon製剤28例(25%)である.全症例の奏効率は36%で,予後では,生存期間中央値(MST)10.2カ月で,1,3,5,7,10年生存率は,それぞれ43.9,10.0,5.6,2.8,2.8%であった.多変量解析にて,奏効に寄与する因子として,腫瘍因子のstageが,予後に寄与する因子として,Child-Pugh score,治療効果,ならびに追加治療の3因子が抽出された.すなわち,肝動注化学療法にて奏効(著効,有効)が得られ,追加治療を行うことが,予後の向上につながると考えられた.

We evaluated the predictors for response and survival in patients with advanced hepatocellular carcinoma (HCC) treated with hepatic arterial infusion chemotherapy (HAIC). A total of 114 patients with advanced HCC were enrolled in this study from our hospital during the previous 12-year period. Patients received one of several regimens of HAIC based on low-dose FP (cisplatin, 5-fluorouracil). Fifteen patients received low-dose FP alone, 71 received low-dose FP and leucovorin or isovorin, and 28 received low dose FP and isovorin with interferon. The overall response rate was 36%, and the overall 1-, 3-, 5-, 7-, and 10-year cumulative survival rates were 43.9, 10.0, 5.6, 2.8, and 2.8%, respectively (Median survival time, 10.2 months). Multivariate analyses showed tumor stage to be a significant predictor for response, and showed Child-Pugh score, therapeutic effect, and additional therapy to be significant predictors for survival. Therefore, we believe that patients who achieved a complete response or partial response and received additional therapies had improved survival.

Journal

Kanzo  

Kanzo 52(7), 449-460, 2011-07-25 

The Japan Society of Hepatology

References:  35

You must have a user ID to see the references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Cited by:  1

You must have a user ID to see the cited references.If you already have a user ID, please click "Login" to access the info.New users can click "Sign Up" to register for an user ID.

Codes

  • NII Article ID (NAID) :
    10029285801
  • NII NACSIS-CAT ID (NCID) :
    AN00047770
  • Text Lang :
    JPN
  • Article Type :
    Journal Article
  • ISSN :
    04514203
  • NDL Article ID :
    11171961
  • NDL Source Classification :
    ZS21(科学技術--医学--内科学)
  • NDL Call No. :
    Z19-130
  • Databases :
    CJP  CJPref  NDL  J-STAGE